In pursuit of compounds which show antimicrobial activity, synthesis of novel morpholine linked substituted chalcones done by condensing different aldehydes with diazotized 4-amino acetophenone coupled to morpholine and evaluated them for in-vitro anticancer, anti-inflammatory and antibacterial activities. The synthesized compounds were screened for anticancer activity against human breast cancer cell lines MCF-7 and MDA-MB-468. In-vitro methods for anti-inflammatory activity like inhibition of bovine albumin denaturation and heat induced hemolysis methods were used. Antibacterial and antitubercular activities were also performed. The structures of synthesized compounds were confirmed based on the IR, 1H NMR and mass spectral data. Among the synthesized compounds, 3HM shown IC50 value of 25 µg against the MCF-7 cell line, whereas 3JM shown IC50 value of 10 µg against MDA-MB-468 cell lines. Compound 3GM has moderate anti inflammatory activity in bovine denaturation and heat induced hemolytic method. Compounds 3DM, 3EM and 3DGM shown MIC of 0.025 µg/ml against Staphylococcus aureus, while compounds 3IM shown MIC of 0.025 µg/ml against E. faecalis. 3AM, 3BM and 3EM is sensitive to Mycobacterium tuberculosis with a MIC of 3.12 µg/ml.
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